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Performance Peptide Therapy

Physician-Supervised Cellular Optimization

What Are Peptides?

Peptides are short chains of amino acids — the fundamental building blocks of protein. But unlike proteins, peptides are small enough to act as precise signaling molecules, communicating directly with cells, tissues, and organ systems to regulate specific biological functions.

At MASI Clinic, peptide therapy is not a supplement protocol. It is precision medicine — physician-designed and supervised by our clinical team, calibrated to your labs, your recovery phase, and your performance goals.

These are the tools elite athletes and high-performing individuals use to sustain output, recover faster, and age on their own terms.

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How do therapeutic peptides work?

Therapeutic peptides work by restoring or amplifying these signals. They don’t introduce foreign chemistry into your body. They use the same molecular language your physiology already speaks — targeting specific receptors to activate healing cascades, modulate inflammation, support hormonal balance, or enhance cellular energy production.

This is why peptide therapy has become one of the most compelling frontiers in regenerative and performance medicine. The specificity is unmatched. A well-selected peptide protocol can target tendon repair, growth hormone release, metabolic efficiency, immune modulation, or cognitive function — with minimal systemic side effects when properly administered.

RECOVERY & TISSUE REPAIR

For athletes, post-surgical patients, and anyone dealing with tendon, ligament, or soft tissue damage that won’t resolve through conventional care.

Consultation Required

WHAT IT IS

BPC-157 (Body Protection Compound) is a synthetic peptide derived from a protective protein found in human gastric juice. TB-500 is a synthetic fraction of Thymosin Beta-4, a naturally occurring repair and regeneration peptide found in virtually every human cell. Together, they form the most clinically validated tissue repair combination in regenerative peptide medicine.

HOW IT WORKS

BPC-157 accelerates angiogenesis — the formation of new blood vessels to injured tissue — while modulating inflammatory cytokines and upregulating growth hormone receptors locally. TB-500 promotes actin polymerization and cell migration, enabling damaged tissue to reorganize and rebuild. The combination creates a synergistic healing environment at the cellular level.

BEST FOR
  • Tendon and ligament injuries (rotator cuff, ACL, Achilles, UCL)
  • Chronic musculoskeletal pain unresponsive to standard treatment
  • Post-surgical tissue healing acceleration
  • Overuse injuries and stress fractures
  • Joint inflammation and articular cartilage support
WHAT TO EXPECT

Most patients notice reduced pain and improved mobility within 2–4 weeks. Full tissue remodeling protocols typically run 8–12 weeks. This is often integrated with PRP or BMAC procedures at MASI Clinic for a multi-layered regenerative approach.

Administered via subcutaneous injection. Protocol designed and monitored by Dr. Reynolds.

GROWTH HORMONE SUPPORT & RECOVERY OPTIMIZATION

For athletes and high performers seeking to restore natural growth hormone pulsatility, accelerate recovery, improve sleep architecture, and support lean body composition — without exogenous HGH.

Consultation Required

WHAT IT IS

CJC-1295 is a growth hormone releasing hormone (GHRH) analogue that stimulates the pituitary gland to produce and release growth hormone in a sustained, physiologic pattern. Ipamorelin is a selective growth hormone secretagogue that amplifies natural GH pulses without significantly affecting cortisol or prolactin — making it one of the cleanest GH-stimulating peptides available.

HOW IT WORKS

Rather than introducing exogenous growth hormone, this combination works with your pituitary to restore the pulsatile GH release patterns that peak in youth and decline with age, stress, and accumulated training load. The result is elevated IGF-1 over time, improved protein synthesis, and enhanced tissue repair — achieved through your own endocrine system.

BEST FOR
  • Athletes seeking improved recovery between training sessions
  • Sleep-deprived high performers (GH is primarily released during deep sleep)
  • Body composition optimization — lean mass support, fat metabolism
  • Post-surgical and post-injury recovery acceleration
  • Adults over 35 experiencing age-related GH decline
WHAT TO EXPECT

Patients typically report improved sleep depth within the first 2 weeks, followed by progressive improvements in recovery, energy, and body composition over 8–12 weeks. This is a long-game protocol — results compound over time.

Administered via subcutaneous injection, typically at bedtime to align with natural GH release patterns.

Consultation Required

WHAT IT IS

Sermorelin is a bioidentical analogue of the first 29 amino acids of endogenous GHRH — the signal your hypothalamus sends to prompt growth hormone release. It is one of the most studied and longest-used GH secretagogues in clinical medicine.

HOW IT WORKS

Sermorelin stimulates the pituitary to release growth hormone through the body’s natural feedback loop, which means the pituitary self-regulates and cannot be overstimulated. This makes it a physiologically elegant and safe option for long-term GH optimization, particularly in patients who prefer a more conservative approach than CJC-1295/Ipamorelin.

BEST FOR
  • Healthy aging and longevity protocols
  • Fatigue, reduced recovery capacity, and declining sleep quality
  • Patients new to GH-axis peptide therapy
  • Muscle recovery, metabolic support, and fat distribution changes

A medical evaluation and baseline labs are required prior to all GH secretagogue protocols.

METABOLIC HEALTH & BODY COMPOSITION

For patients seeking physician-supervised support for weight management, insulin sensitivity, and metabolic optimization — with muscle preservation as a non-negotiable priority.

Consultation Required

WHAT IT IS

Tirzepatide is a dual GIP/GLP-1 receptor agonist — one of the most clinically significant advances in metabolic medicine in decades. At MASI Clinic, it is paired with glycine to support muscle preservation and connective tissue health during weight loss, distinguishing our approach from standard weight loss programs.

HOW IT WORKS

Tirzepatide works through two complementary pathways: GLP-1 receptor agonism slows gastric emptying and reduces appetite signaling, while GIP receptor agonism enhances insulin sensitivity and supports fat cell metabolism. The combined effect produces meaningful, sustained weight reduction with favorable effects on blood glucose, lipids, and inflammatory markers. Glycine co-administration supports collagen synthesis and mitochondrial function, protecting lean tissue during caloric restriction.

BEST FOR
  • Adults with metabolic syndrome, insulin resistance, or type 2 diabetes
  • High performers seeking body recomposition without sacrificing muscle
  • Patients who have plateaued with lifestyle intervention alone
  • Weight optimization prior to orthopedic procedures
WHAT TO EXPECT

Most patients see meaningful weight reduction within 4–8 weeks. Protocols are titrated carefully to minimize gastrointestinal side effects. Lab monitoring, body composition tracking, and regular provider check-ins are standard components of this program at MASI Clinic.

This is a physician-prescribed protocol. Medical evaluation, labs, and ongoing monitoring required.

Consultation Required

WHAT IT IS

MOTS-c is a mitochondrial-derived peptide — encoded directly in mitochondrial DNA — that regulates metabolic homeostasis at the cellular level. It is one of the most exciting emerging peptides in longevity and metabolic medicine.

HOW IT WORKS

MOTS-c activates AMPK, the cellular energy sensor that governs metabolic efficiency, insulin sensitivity, and mitochondrial biogenesis. It enhances the cell’s ability to utilize glucose and fatty acids for energy production, reduces systemic inflammation, and supports metabolic resilience under physiological stress including exercise and caloric restriction.

BEST FOR
  • Athletes seeking improved metabolic efficiency and endurance performance
  • Patients with insulin resistance or metabolic syndrome
  • Longevity protocols targeting mitochondrial health
  • High performers experiencing energy dysregulation or metabolic fatigue
WHAT TO EXPECT

MOTS-c is typically used as part of a broader metabolic optimization protocol. Clinical effects on energy, exercise tolerance, and insulin sensitivity develop over 4–8 weeks of consistent use.

LONGEVITY & CELLULAR HEALTH

Protocols designed for patients committed to long-term cellular defense, cognitive preservation, and the extension of their high-performance healthspan.

See IV Therapy page for IV options

WHAT IT IS

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell, essential for mitochondrial energy production, DNA repair, and the activation of sirtuins — the longevity proteins that regulate cellular aging. NAD+ levels decline 50% or more between young adulthood and midlife, accelerated by stress, poor sleep, alcohol, and high training loads.

HOW IT WORKS

NAD+ therapy restores cellular energy production through the electron transport chain, activates SIRT1 and SIRT3 (key longevity pathways), supports DNA repair mechanisms, and modulates neuroinflammation. At the cellular level, it is one of the most upstream interventions in performance and longevity medicine.

BEST FOR
  • Cognitive decline, brain fog, and mental performance optimization
  • Recovery from burnout, illness, or sustained high-stress periods
  • Athletic recovery and mitochondrial performance support
  • Longevity protocols — SIRT pathway activation
  • Substance recovery support and neurological restoration

Available as IV infusion (highest bioavailability) or subcutaneous injection. See our Performance IV Therapy page for IV NAD+ pricing and protocols.

IMMUNE & COGNITIVE RESILIENCE

For high performers under sustained cognitive demand, immune stress, or neurological fatigue — including athletes managing training load, executives operating at peak cognitive output, and patients recovering from illness or neurological stress.

Consultation Required

WHAT IT IS

Thymosin Alpha-1 is a naturally occurring peptide produced by the thymus gland that plays a central role in T-cell maturation and immune system regulation. It is used clinically in over 35 countries for immune modulation in viral infections, cancer adjunct therapy, and chronic immune deficiency states.

HOW IT WORKS

Thymosin Alpha-1 modulates both innate and adaptive immunity — increasing natural killer cell activity, enhancing T-helper cell function, and regulating inflammatory cytokine production. It does not overstimulate the immune system; it recalibrates it toward more efficient, targeted immune response.

BEST FOR
  • Chronic infections, post-viral fatigue, and immune dysregulation
  • Athletes with high training load suppressing immune function
  • Patients seeking proactive immune resilience protocols
  • Autoimmune conditions (with physician evaluation)

Consultation Required

WHAT IT IS

Selank is a synthetic analogue of tuftsin — an immunomodulatory peptide with potent anxiolytic and nootropic properties. Semax is a synthetic ACTH analogue with well-documented neuroprotective and cognitive-enhancing effects, widely used in Russian clinical medicine for neurological conditions and cognitive optimization.

HOW IT WORKS

Selank modulates GABA receptor activity and increases BDNF (brain-derived neurotrophic factor) expression, producing anxiolytic effects without sedation or dependence — making it fundamentally different from benzodiazepines. Semax stimulates BDNF and NGF synthesis, enhancing synaptic plasticity, dopaminergic tone, and working memory capacity. Together, they address both the emotional and cognitive dimensions of high-performance brain function.

BEST FOR
  • Executives and high performers seeking cognitive edge without stimulants
  • Anxiety, stress reactivity, and HPA axis dysregulation
  • Athletes managing performance anxiety or focus under pressure
  • Neurological recovery and post-concussion support
  • Brain fog, mental fatigue, and working memory decline
WHAT TO EXPECT

Many patients report noticeable improvements in mental clarity, stress tolerance, and focus within the first week. These peptides are administered intranasally or subcutaneously and are typically used in 4–8 week cycles.

SKIN & TISSUE REJUVENATION

Peptide-based protocols that work at the dermis level — supporting collagen synthesis, skin architecture, and tissue regeneration from the inside out. Not aesthetics. Regenerative biology.

Consultation Required

WHAT IT IS

GHK-Cu is a naturally occurring copper-binding peptide found in human plasma, saliva, and urine. Plasma levels decline significantly with age and correlate with reduced skin quality, wound healing capacity, and tissue regeneration. The GLOW Protocol at MASI Clinic pairs GHK-Cu with complementary peptides to address skin aging, hair follicle health, and systemic tissue regeneration.

HOW IT WORKS

GHK-Cu activates over 4,000 genes involved in tissue repair, collagen and elastin synthesis, antioxidant defense, and anti-inflammatory signaling. It stimulates dermal fibroblasts, promotes skin tightening, and supports hair follicle cycling. Systemically, it modulates TGF-beta signaling and reduces excess fibrinogen — factors implicated in chronic inflammation and tissue fibrosis.

BEST FOR
  • Skin laxity, fine lines, and loss of dermal density
  • Hair thinning and follicle health support
  • Wound healing and post-procedure skin recovery
  • Systemic anti-aging protocols targeting connective tissue integrity
  • Athletes and active patients with chronic skin stress from sun and environment
WHAT TO EXPECT

Skin quality improvements are typically visible at 6–8 weeks. Hair follicle response requires 3–6 months of consistent protocol. The GLOW Protocol is commonly integrated with NAD+ IV therapy and CJC-1295/Ipamorelin for a comprehensive cellular rejuvenation approach.

Consultation Required

WHAT IT IS

Methylcobalamin is the bioactive, methylated form of vitamin B12 — the form your neurons actually use. Unlike cyanocobalamin (the synthetic form found in most supplements), methylcobalamin crosses the blood-brain barrier effectively and supports neurological function directly.

BEST FOR
  • Fatigue, especially with neurological or cognitive components
  • Athletes and high performers with high B12 utilization demand
  • Patients on plant-based diets or proton pump inhibitors
  • Peripheral neuropathy and nerve conduction support
  • Methylation cycle support in patients with MTHFR variants

Often combined with other peptide protocols as a foundational metabolic support.

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How We Approach Peptide Therapy at MASI Clinic

Every peptide protocol at MASI Clinic begins with a comprehensive physician consultation — not a wellness intake form. Dr. Reynolds reviews your health history, current training and performance demands, relevant labs, and specific goals before recommending any protocol.

Peptides are compounded through FDA-regulated 503A and 503B pharmacies, ensuring pharmaceutical-grade purity and dosing accuracy. This is not a supplement program. It is physician-directed, evidence-informed regenerative medicine.

“We don’t prescribe protocols. We build them — specific to your biology, your goals, and your timeline.”

Schedule a Peptide Consultation

Available at MASI Clinic Santa Cruz and San Jose (Santana Row).

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The MASI Method

Dr. Masi’s four-pillar approach to healing and performance integrates soul, structure, biology, and mindset. Mana is the life force that encompasses and is at the root of all, inherent in each individual and honoring the deeper connection between spirit, purpose, and healing. The Anatomical pillar focuses on structural care through orthopedic expertise, surgery, and rehabilitation. The Systemic pillar addresses cellular and physiological healing with regenerative therapies such as stem cells, PRP, peptides, and anti-inflammatory protocols. Finally, the Interoception pillar centers on mindset and self-awareness—cultivating belief, agency, and resilience as essential drivers of recovery and long-term performance.

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